Cidofovir → [(2R)-1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
반응식
C1O[C@H]1CO.C(NC1C=CNC(=O)N=1)(=O)C1C=CC=CC=1.[CH:22]1[C:28]([NH2:29])=[N:27][C:25](=[O:26])[N:24]([CH2:30][C@H:31]([O:34][CH2:35][P:36]([OH:39])([OH:38])=[O:37])[CH2:32][OH:33])[CH:23]=1>>[CH:22]1[C:28]([NH2:29])=[N:27][C:25](=[O:26])[N:24]([CH2:30][C@@H:31]([O:34][CH2:35][P:36]([OH:39])([OH:38])=[O:37])[CH2:32][OH:33])[CH:23]=1참가 물질
4
실험 절차
The title compound (R)-HPMPC was prepared from (S)-glycidol (88% ee) and N4 -benzoylcytosine, following the method described for (S)-HPMPC.
출처 및 근거
- ORD 기록
- ord-bfc1ba919bfc4fa29b2b10f0b66d2b44
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05591852
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