Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexanol → 3-Cyclohexyloxy-6,7-dimethoxy-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexanol | HCID 7966 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 반응물 | 6,7-Dimethoxyquinolin-3-ol | HCID 10058766 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Cyclohexyloxy-6,7-dimethoxy-quinoline | HCID 9904018 | — |
반응 단계
To a THF solution (30 mL) at 0° C. is added 3-hydroxy-6,7-dimethoxyquinoline (0.237 g, 1.15 mmol), cyclohexanol (0.347 g, 3.46 mmol), Ph3P (0.908 g, 3.46 mmol). Diethylazodicarboxylate is added portionwise until the solution retained a deep red color (0.663 g, 3.81 mmol). After 4 hours the solution is concentrated and the residue chromatographed (50% EtOAc in hexanes). The product is recrystallized from isopropanol/hexanes as the HCl salt as a white solid (m.p. 229-232° C., dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852712B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-08e2a2c1bd0947beb25af09a094e127e |
| 출처 메모 | uspto-grants-2005_02 |