Water → 7-Amino-3-(pyrrolo-[1,2-a]pyrazinium-2-yl)methyl-3-cephem-4-carboxylate

HRID 233466

반응식

HRID 233466 반응식
[NH2:1][CH:2]1[C:14](=[O:15])[N:4]2[C:5]([C:11]([O-:13])=[O:12])=[C:6]([CH2:9]I)[CH2:7][S:8][C@H:3]12.[CH:16]1[C:17]2[N:18]([CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:20][N:21]=1.O>C(#N)C>[NH2:1][CH:2]1[C:14](=[O:15])[N:4]2[C:5]([C:11]([O-:13])=[O:12])=[C:6]([CH2:9][N+:21]3[CH:20]=[CH:19][N:18]4[CH:22]=[CH:23][CH:24]=[C:17]4[CH:16]=3)[CH2:7][S:8][C@H:3]12

참가 물질

5

반응물 3

HCID 962WaterHCID 11018843Pyrrolo(1,2-a)pyrazineHCID 1317197827-Amino-3-iodomethyl-3-cephem-4-carboxylate

생성물 1

HCID 677046707-Amino-3-(pyrrolo-[1,2-a]pyrazinium-2-yl)methyl-3-cephem-4-carboxylate수율 93%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
0 °C

실험 절차

2.5 g of 7-amino-3-iodomethyl-3-cephem-4-carboxylate was suspended in 30 ml of acetonitrile; and 2 ml bistrimethyl-silylacetamide was added thereto. To the mixture was added 2 g of pyrrolo[1,2-a]pyrazine prepared in Preparation Example 1. The reaction mixture was reacted at 10° C. for 1 hour and then cooled to 0° C. To this solution was added 0.6 ml of water; and the resulting mixture was filtered and then washed with 30 ml of cold acetonitrile to obtain 2.4 g of light yellow title compound (yield: 93%).

후처리

  1. customprepared in Preparation Example 1
  2. customThe reaction mixture was reacted at 10° C. for 1 hour
  3. filtrationand the resulting mixture was filtered
  4. washwashed with 30 ml of cold acetonitrile

출처 및 근거

ORD 기록
ord-59107c343c3e42538453b1fadfae0718
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593984

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