Water → HCID 54430516, 화합물

HRID 233491노트

반응식

HRID 233491 반응식
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[OH:12][CH2:13][CH2:14][NH:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18].[OH2:21]>N1C=CC=CC=1>[CH3:11][C:1]1[CH:6]=[CH:5][C:4]([S:7]([N:15]([CH2:16][C:17]([CH3:20])([OH:19])[CH3:18])[CH2:14][CH2:13][O:12][S:7]([C:4]2[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=2)(=[O:8])=[O:21])(=[O:9])=[O:8])=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 149870161-[(2-Hydroxyethyl)amino]-2-methyl-2-propanol

생성물 1

HCID 54430516HCID 54430516, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-Toluenesulfonyl chloride (166.1 g) was added portionwise to a stirred solution of 1-[(2-hydroxyethyl)amino]-2-methyl-2-propanol (58.0 g) in pyridine (275 ml) at 0°-10° C. The resulting solution was stirred at room temperature for 15 h and then poured into water (1 l). The mixture was extracted with dichloromethane and the organic phase was washed with hydrochloric acid (2.5M) and brine. After drying over magnesium sulfate, the solvent was removed under reduced pressure to give 1-{N-[(4-methylphenyl)sulfonyl]-N-[(4-methylphenyl)sulfonyloxyethyl]amino}-2-methyl-2-propanol (155.8 g). δ (CDCl3) 1.23 (s,6H), 2.44,2.46 (6H), 3.08 (s,2H), 3.45 (t,2H), 4.35 (t,2H) and 7.25-7.85 (m,8H).

후처리

  1. extractionThe mixture was extracted with dichloromethane
  2. washthe organic phase was washed with hydrochloric acid (2.5M) and brine
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-0ef93d24f82a486092953910db92c95c
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593983

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