Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexylthiourea → 7-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexylthiourea | HCID 1471603 | — |
| 반응물 | Bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde | HCID 135531132 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one | HCID 135496165 | — |
반응 단계
A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852720B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-25238562fd52496693cf85f9c426924f |
| 출처 메모 | uspto-grants-2005_02 |