Dimethylformamide → 5-(2-Chloro-pyridin-4-ylethynyl)-3-(4-fluoro-phenyl)-2-methyl-3H-imidazole-4-carbaldehyde

반응식

[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:23][N:24]([CH:25]=[O:26])[CH3:27].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][c:10]2[n:11][c:12]([CH3:22])[n:13](-[c:15]3[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]3)[cH:14]2)[cH:7]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][c:10]2[n:11][c:12]([CH3:22])[n:13](-[c:15]3[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]3)[c:14]2[CH:25]=[O:26])[cH:7]1

참가 물질

반응물 3

HCID 6228Dimethylformamide

HCID 8028Tetrahydrofuran

HCID 112783692-Chloro-4-[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

생성물 1

HCID 866029665-(2-Chloro-pyridin-4-ylethynyl)-3-(4-fluoro-phenyl)-2-methyl-3H-imidazole-4-carbaldehyde

출처 및 근거

ORD 기록: ord-b53981354de84a32b968e491b651a781
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

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