Methyl 3-phenyl-DL-alaninate hydrochloride → N-[(2-benzothiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester

HRID 233698

반응식

HRID 233698 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11](N1C=CN=C1)=[S:12].Cl.[CH3:19][O:20][C:21](=[O:31])[CH:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[NH2:23]>CN(C)C=O>[CH3:19][O:20][C:21](=[O:31])[CH:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[NH:23][C:11]([NH:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[S:12]

참가 물질

4

반응물 2

HCID 3084017Methyl 3-phenyl-DL-alaninate hydrochlorideHCID 19703709N-(benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide

생성물 1

HCID 19703398N-[(2-benzothiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester수율 70.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 1-[(2-benzothiazolyl)thiocarbamoyl]imidazole (1.30 g, 5.0 mmol) and DL-phenylalanine methyl ester hydrochloride (1.08 g, 5.0 mmol) in N,N-dimethylformamide (50 mL) was heated at 90° C. for 3 h. The reaction was cooled to room temperature, solvent removed under reduced pressure, recrystalllized from ethyl ether-hexanes to provide 1.31 g (70%) of the titled product:

후처리

  1. customsolvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-d26e212ec36043ca9a12ae547561e4c5
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593993

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