2-Amino-4,5,6,7-tetrahydrobenzothiazole → HCID 19703901, 화합물

HRID 233704

반응식

HRID 233704 반응식
[C:1]1([CH2:7][CH2:8][N:9]=[C:10]=[S:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[NH2:12][C:13]1[S:14][C:15]2[CH2:21][CH2:20][CH2:19][CH2:18][C:16]=2[N:17]=1>CN(C)C=O>[C:1]1([CH2:7][CH2:8][NH:9][C:10]([NH:12][C:13]2[S:14][C:15]3[CH2:21][CH2:20][CH2:19][CH2:18][C:16]=3[N:17]=2)=[S:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

참가 물질

4

반응물 2

HCID 180462-Amino-4,5,6,7-tetrahydrobenzothiazoleHCID 27358811-(2-Isothiocyanatoethyl)cyclohex-1-ene

생성물 1

HCID 19703901HCID 19703901, 화합물수율 13.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2-(1-cyclohexenyl)ethyl isothiocyanate (1.67 g, 10 mmol) and 2-amino-4,5,6,7-tetrahydrobenzothiazole (1.54 g, 10 mmol) in N,N-dimethylformamide (100 mL) was heated at 100° C. for 120 h. The reaction was cooled to room temperature, the solvent removed under reduced pressure, the residue taken up in ethyl acetate and washed with 1N HCl. The organic layer was concentrated and the residue recrystallized from ethyl acetate-hexanes to provide 426 mg (13%) of the titled product:

후처리

  1. customthe solvent removed under reduced pressure
  2. washwashed with 1N HCl
  3. concentrationThe organic layer was concentrated
  4. customthe residue recrystallized from ethyl acetate-hexanes

출처 및 근거

ORD 기록
ord-d5c227c25b4b45b1b6cd865fee535c41
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593993

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