1,1'-Thiocarbonyldiimidazole → 1-[(2-(2,6-Difluorophenyl)ethyl)thiocarbamoyl]imidazole

HRID 233717노트

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HRID 233717 반응식
[C:1]([N:8]1[CH:12]=[CH:11]N=C1)([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[S:2].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1CCN>C(#N)C>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[CH2:11][CH2:12][NH:8][C:1]([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[S:2]

참가 물질

4

반응물 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 37461112-(2,6-Difluorophenyl)ethan-1-amine

생성물 1

HCID 152056241-[(2-(2,6-Difluorophenyl)ethyl)thiocarbamoyl]imidazole수율 124.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 1,1'-thiocarbonyldiimidazole (9.5 g, 48 mmol) and 2-(2,6-difluorophenyl)ethylamine (7.54 g, 48 mmol) in acetonitrile (100 mL) was stirred at room temperature for 20 h. The solution was concentrated under reduced pressure and the resulting precipitate was collected by filtration and triturated with hexane to provide 16 g of crude titled product as a brown solid:

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. filtrationthe resulting precipitate was collected by filtration
  3. customtriturated with hexane

출처 및 근거

ORD 기록
ord-f9599652d4ff4e9fb0257b9743d8df4c
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593993

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