Tranylcypromine, cis- → (+)-N-(cis-2-phenylcyclopropyl)-N'-(5-chloropyrid-2-yl)thiourea

HRID 233739노트

반응식

HRID 233739 반응식
[C:1]1([C@H:7]2[CH2:9][C@H:8]2[NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([NH:18][C:19](N2C=CN=C2)=[S:20])=[N:16][CH:17]=1>>[C:1]1([C@H:7]2[CH2:9][C@H:8]2[NH:10][C:19]([NH:18][C:15]2[CH:14]=[CH:13][C:12]([Cl:11])=[CH:17][N:16]=2)=[S:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 6971118Tranylcypromine, cis-HCID 10823879N-(5-Chloropyridin-2-yl)-1H-imidazole-1-carbothioamide

생성물 1

HCID 22868897(+)-N-(cis-2-phenylcyclopropyl)-N'-(5-chloropyrid-2-yl)thiourea

실험 절차

(-)-N-cis-2-phenylcyclopropylamine (0.23 g, 1.7 mmol) from Example 423 was condensed with 1-(5-chloropyrid-2-yl-thiocarbamoyl)-imidazole (0.4 g, 1.7 mmol) according to the procedure of Example 372 to yield the titled product as crystals.

출처 및 근거

ORD 기록
ord-2930949b6fcd4e8296d9d66cd582537e
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593993

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