Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 5-HT6/7 antagonist 1 | HCID 9865357 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane ethanol | HCID 21584144 | — |
| 생성물 | N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride | HCID 18467219 | — |
반응 단계
To a solution of 8.0 g of N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide in dichloromethane/ethanol (150 ml) was added 1M - HCl in ether. The salt crystallized out rapidly. It was filtered off, washed with ethanol and dried to afford 8.15 g withm.p.=257°-259° C., dec. Recrystallization provided 7.20 g of pure white salt, with m.p. unchanged.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05593995 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-2c981c39c6fc4fd99c0e3a819728978a |
| 출처 메모 | uspto-grants-1997_01 |