Dimethylamine → 2-nitrobenzyl-N,N-dimethylsulfonamide

HRID 23394

반응식

HRID 23394 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][S:11](Cl)(=[O:13])=[O:12])([O-:3])=[O:2].[CH3:15][NH:16][CH3:17]>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][S:11]([N:16]([CH3:17])[CH3:15])(=[O:13])=[O:12])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 4305447(2-nitrophenyl)methanesulfonyl Chloride

생성물 1

HCID 131787262-nitrobenzyl-N,N-dimethylsulfonamide수율 85%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2-Nitro-α-toluenesulfonyl chloride (0.943 g, 4.0 mmole) was dissolved in dry dioxane (7 ml) and treated with a solution of dimethylamine (4 ml 2M solution in THF, 8.0 mmole), and stirred at room temperature for a total of 6 h. The reaction mixture was transferred to a separatory funnel and partitioned between ethyl acetate and water. The organic solution was washed with brine, dried over magnesium sulfate, filtered and evaporated to dryness to afford the pure 2-nitrobenzyl-N,N-dimethylsulfonamide, 0.829 g (85% yield).

후처리

  1. customThe reaction mixture was transferred to a separatory funnel
  2. custompartitioned between ethyl acetate and water
  3. washThe organic solution was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-72587823e0244b7bbf8e4b0bdd642b13
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852726B2

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