Thionyl Chloride → 3-(Chloromethyl)-1,1'-biphenyl

반응식

O[CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:17])=O>>[Cl:17][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 6035563-Biphenylmethanol

생성물 1

HCID 154808923-(Chloromethyl)-1,1'-biphenyl

실험 절차

A solution of 50 mg of 3-hydroxymethylbiphenyl in 1.5 mL thionyl chloride was heated at reflux temperature for 4 hr, cooled to room temperature and the solvent removed by evaporation under reduced pressure to yield 45 mg of 3-chloromethylbiphenyl which was used in the next step without further purification or characterization.

후처리

temperatureat reflux temperature for 4 hr
customthe solvent removed by evaporation under reduced pressure

출처 및 근거

ORD 기록: ord-60819a95f61e40049c38989c56097a1a
출처 데이터셋: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05594141

반응 노트

불러오는 중…