Trifluoroacetic acid → [[4-[[N-[3-(piperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetic acid trifluoroacetate

HRID 234134노트

반응식

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16]([N:18]([CH2:20][C:21]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])=[C:25]([O:38][CH2:39][C:40]([O:42]C(C)(C)C)=[O:41])[CH:24]=2)=[O:22])[CH3:19])=[O:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16]([N:18]([CH2:20][C:21]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]([OH:33])=[O:32])=[C:25]([O:38][CH2:39][C:40]([OH:42])=[O:41])[CH:24]=2)=[O:22])[CH3:19])=[O:17])[CH2:10][CH2:9]1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 54497635Di-t-butyl [[4-[[N-[3-(1-t-butyloxycarbonylpiperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetate

생성물 1

HCID 67624455[[4-[[N-[3-(piperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetic acid trifluoroacetate

실험 절차

The solution of 250 mg of the compound prepared in (a) in 2 ml of trifluoroacetic acid was stirred at room temperature for 3 hours. After the solvent was evaporated under reduced pressure, ether was added and deposited crystals were collected by filtration to give 168 mg of the title compound.

후처리

customAfter the solvent was evaporated under reduced pressure, ether
additionwas added
filtrationwere collected by filtration

출처 및 근거

ORD 기록: ord-7b7f4c3789e543b4a10302d94a473116
출처 데이터셋: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05594004

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