HCID 53884272, 화합물 → 2-Acetyl-5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 234138노트

반응식

HRID 234138 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([C:17](NCCC3C=CC(OCC(OCC)=O)=C(OCC(OCC)=O)C=3)=[O:18])=[CH:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=C[CH:48]=1>ClCCl>[C:17]([C:15]1[S:14][C:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9][C:10]=2[CH:16]=1)(=[O:18])[CH3:48]

참가 물질

4

반응물 2

HCID 53884272HCID 53884272, 화합물HCID 178418287HCID 178418287, 화합물

생성물 1

HCID 214659752-Acetyl-5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine수율 191.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the solution of the compound prepared in (a) (847 mg) in dichloromethane (30 ml) was added Molecular Sieves 4A (3 g), followed by pyridinium chlorochromate (966 mg) under ice-cooling. The mixture was stirred for 40 minutes. After the reaction mixture was filtered through FLORISIL, the filtrate was concentrated to give 772 mg of 2-acetyl-5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (yield, 92%).

후처리

  1. temperaturecooling
  2. filtrationAfter the reaction mixture was filtered through FLORISIL
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-2ce59e35fdf048fda1e87bc9eb260e69
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594004

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