2,5-Dichlorothiophene-3-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide

HRID 234301

반응식

HRID 234301 반응식
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[S:11][C:12]([Cl:19])=[CH:13][C:14]=1[S:15](Cl)(=[O:17])=[O:16]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:15]([C:14]1[CH:13]=[C:12]([Cl:19])[S:11][C:10]=1[Cl:9])(=[O:17])=[O:16]

참가 물질

3

반응물 2

HCID 27360942,5-Dichlorothiophene-3-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

생성물 1

HCID 15342064N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide수율 47%

실험 절차

N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 2,5-dichlorothiophene-3-sulphonyl chloride in 47% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 135°-138° C.

후처리

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 135°-138° C.

출처 및 근거

ORD 기록
ord-451f5ebd67574ae98b00f67cf3b07dec
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594021

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