4,5-Dichlorothiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-4,5-dichlorothiophene-2-sulfonamide

HRID 234303

반응식

HRID 234303 반응식
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:11]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[S:13][C:14]=1[Cl:15]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:16]([C:12]1[S:13][C:14]([Cl:15])=[C:10]([Cl:9])[CH:11]=1)(=[O:18])=[O:17]

참가 물질

3

반응물 2

HCID 5186224,5-Dichlorothiophene-2-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

생성물 1

HCID 15342066N-(4-Bromo-3-methyl-5-isoxazolyl)-4,5-dichlorothiophene-2-sulfonamide수율 42%

실험 절차

N-(4-Bromo-3-methyl-5-isoxazolyl)-4,5-dichlorothiophene-2-sulfonamide was prepared in the same manner as described in Example 1 from 5-amino-4-bromo-3-methylisoxazole and 4,5-dichlorothiophene-2-sulphonyl chloride in 42% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 135°-138° C.

후처리

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 135°-138° C.

출처 및 근거

ORD 기록
ord-883c369a951b4cc29a0703a43913cd8d
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594021

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