Boronic acid, (4-ethylphenyl)- → HCID 23445382, 화합물

HRID 234320

반응식

HRID 234320 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)[CH3:2].Br[C:13]1[S:17][C:16]([S:18]([N:21]2[CH:25]=[CH:24][CH:23]=[CH:22]2)(=[O:20])=[O:19])=[CH:15][CH:14]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:13]2[S:17][C:16]([S:18]([N:21]3[CH:25]=[CH:24][CH:23]=[CH:22]3)(=[O:19])=[O:20])=[CH:15][CH:14]=2)=[CH:5][CH:4]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

생성물 1

HCID 23445382HCID 23445382, 화합물수율 81%

실험 절차

N-[5-(4-ethylphenyl)thiophene-2-sulfonyl]pyrrole was prepared, in the same manner as described in Example 32C, from 4-ethylphenylboronic acid and N-(5-bromothiophenesulfonyl)pyrrole. Purification by column chromatography using 10% ethyl acetate/hexanes gave the pure sulfonamide as a tan solid in 81% yield.

후처리

  1. customPurification by column chromatography

출처 및 근거

ORD 기록
ord-3cfad4bb7beb4ac99de8b03712869ff0
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594021

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