Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 4-Methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Methylthiazole-5-carboxaldehyde | HCID 581339 | — |
| 반응물 | Arsonium, (3-methyl-2-oxobutyl)triphenyl-, bromide | HCID 11465575 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one | HCID 53814806 | — |
반응 단계
The title compound was prepared as described in General Method 1 using 1.4 g (11.0 mmol) of 4-methyl-5-thiazolecarbaldehyde (Example A-12), 6.2 g (13.1 mmol) of (3-methyl-2-oxobutyl)triphenylarsonium bromide, 1.8 g (13.1 mmol) of potassium carbonate, 75 mL of acetonitrile, and 0.75 mL of H2O. Chromatography of the residue, eluting with 3:1 hexane:EtOAc gave the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852711B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-b6a0b864235042f99a35593d3de787e0 |
| 출처 메모 | uspto-grants-2005_02 |