Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Formylphenylboronic acid → N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Formylphenylboronic acid | HCID 292189 | — |
| 반응물 | N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide | HCID 22998516 | — |
| 생성물 | N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide | HCID 22998472 | 28% |
반응 단계
N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 32C from 2-formylbenzeneboronic acid (281 mg, 1.87 mmol) and N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide (550 mg, 1.7 mmol). Purification by column chromatography using 15% MeOH/CHCl3 gave 63 mg (28%) of the pure sulfonamide as a brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05594021 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-7792e2d006364e329d565325598d9ef0 |
| 출처 메모 | uspto-grants-1997_01 |