Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Calcium Carbonate → 2-Bromo-5-fluorobenzyl alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Calcium Carbonate | HCID 10112 | — |
| 반응물 | 1-Bromo-2-(bromomethyl)-4-fluorobenzene | HCID 517972 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Bromo-5-fluorobenzyl alcohol | HCID 2773349 | — |
반응 단계
2-Bromo-5-fluorobenzylbromide (2.0 g, 7.46 mmol) was dissolved in dioxane (25 mL) and H2O (25 mL), and CaCO3 (3.84 g, 38.39 mmol) was added. The mixture was heated to reflux overnight. The solution was concentrated, and the residue was partitioned between H2O and CH2Cl2. The organic phase was washed with 1N HCl and brine, dried (MgSO4), filtered, and concentrated to afford the title compound. 1H NMR (CDCl3): δ 2.00 (t, 1H), 4.72 (d, 2H), 6.85-6.92 (m, 1H), 7.26 (dd, 1H), 7.48 (dd, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852711B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-1076bffe427846ac8eb8c24fef4f4f01 |
| 출처 메모 | uspto-grants-2005_02 |