Phosphorus pentachloride → 4-(Chlorocarbonyl)-3-fluorophenyl acetate
반응식
[F:1][C:2]1[CH:10]=[C:9]([O:11][C:12](=[O:14])[CH3:13])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C1C=CC=CC=1>[F:1][C:2]1[CH:10]=[C:9]([O:11][C:12](=[O:14])[CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:16])=[O:5]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
Then, in a 100 ml-reaction vessel, 9.5 g (4.80×10-2M) of 2-fluoro-4-acetoxybenzoic acid and 50 ml of dry benzene were placed. To the mixture, 10.3 g (4.94×10-2M) of phosphorus pentachloride was added in 30 minutes at room temperature, followed by stirring for 4 hours at 50° C. After cooling, the solvent of the reaction mixture was distilled off to provide oily 2-fluoro-4-acetoxy-benzoyl chloride.
후처리
- temperatureAfter cooling
- distillationthe solvent of the reaction mixture was distilled off
출처 및 근거
- ORD 기록
- ord-ae92e232a5b24544ac30f5ceea5f034d
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05595685
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