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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 234713생성일: 2026년 10월 25일

Sodium Hydroxide → (1-Dibenzylaminocarbonyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetic acid

https://huagongshe.com/reaction/234713

반응식

참여 물질

역할이름HCID투입량
반응물Sodium HydroxideHCID 14798—
반응물Methyl(1-dibenzylaminocarbonyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetateHCID 15230236—
용매MethanolHCID 887—
용매1,2-DimethoxyethaneHCID 8071—
생성물(1-Dibenzylaminocarbonyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetic acidHCID 1523023786.6%

반응 단계

To a solution of the compound prepared in example 1 (204 mg) in dimethoxyethane (3 ml) and methanol (2 ml) was added 1N aqueous solution of sodium hydroxide. After stirred for 2 h, the mixture was quenched by addition of 1N hydrochloric acid. The mixture was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium salfate, and evaporated. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4→ethyl acetate) to give the title compound (171 mg) having the following physical data.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05596009
출처 데이터셋uspto-grants-1997_01
ORD IDord-3a0c3e53415645eba0254c2e93098166
출처 메모uspto-grants-1997_01