Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → (1-Dibenzylaminocarbonyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl(1-dibenzylaminocarbonyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetate | HCID 15230236 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | (1-Dibenzylaminocarbonyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetic acid | HCID 15230237 | 86.6% |
반응 단계
To a solution of the compound prepared in example 1 (204 mg) in dimethoxyethane (3 ml) and methanol (2 ml) was added 1N aqueous solution of sodium hydroxide. After stirred for 2 h, the mixture was quenched by addition of 1N hydrochloric acid. The mixture was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium salfate, and evaporated. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4→ethyl acetate) to give the title compound (171 mg) having the following physical data.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05596009 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-3a0c3e53415645eba0254c2e93098166 |
| 출처 메모 | uspto-grants-1997_01 |