Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Sodium Bromide | HCID 253881 | — |
| 반응물 | Sodium thiocyanate | HCID 516871 | — |
| 반응물 | 5-Isopropyl-2-nitroaniline | HCID 22572852 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine | HCID 22572913 | — |
반응 단계
The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852711B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-233cc62428524c4396e8779a88af5ae1 |
| 출처 메모 | uspto-grants-2005_02 |