Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl trans-crotonate → Ethyl 4-methyl-1h-pyrrole-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl trans-crotonate | HCID 429065 | — |
| 반응물 | p-Toluol sulfonylmethyliso-cyanide | HCID 86750240 | — |
| 생성물 | Ethyl 4-methyl-1h-pyrrole-3-carboxylate | HCID 235044 | — |
| 생성물 | 3,4-Dimethylpyrrole | HCID 5324584 | — |
반응 단계
Based on D. O. Cheng, T. L. Bowman, E. LeGoff, J. Heterocyclic Chem. 13, 1145 (1976), 3,4-dimethylpyrrole was synthesized starting from p-toluol-sulfonylmethyliso-cyanide and crotonic-acid-ethyl-ester. The dimethyl compound was quickly obtained after reduction of the intermediary 3-(ethoxycarbonyl)-4-methylpyrrole, but at only 18% total yield. The material had a melting point of 25°-28° C. H-NMR (CDCl3): 2.04 (s, 6H), 6.50 (d, 2H), 7.33 (s br, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05597471 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-5f12b5c4b65f4ad3aa4980da30b05451 |
| 출처 메모 | uspto-grants-1997_01 |