2,4-Dichlorophenylacetonitrile → 6-Benzyloxymethyl-2,4-diamino-5-(2,4-dichlorophenyl)pyrimidine

HRID 234929

반응식

HRID 234929 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11](Cl)[C:10]=2[Cl:16])=[C:4]([CH2:17][O:18][CH3:19])[N:3]=1.[Cl:20]C1C=C(Cl)C=CC=1CC#N.C(OCC(OCC)=O)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:19]([O:18][CH2:17][C:4]1[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([NH2:8])[C:5]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:20])=[CH:11][C:10]=1[Cl:16])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

참가 물질

4

반응물 3

HCID 805662,4-DichlorophenylacetonitrileHCID 290299Ethyl 2-(benzyloxy)acetateHCID 115222652,4-Diamino-5-(2,3-dichlorophenyl)-6-methoxymethylpyrimidine

생성물 1

HCID 115236576-Benzyloxymethyl-2,4-diamino-5-(2,4-dichlorophenyl)pyrimidine

실험 절차

This compound was prepared in a manner analogous to the compound of Example 16 from 2,4-dichlorophenylacetonitrile and ethyl benzyloxyacetate, 3.77 gms, mp. 171°-172° C.

출처 및 근거

ORD 기록
ord-b340b204a63f47dcbcbe6ce517894b9c
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597827

연결된 노트

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