Potassium Cyanide → 2-(3,5-Dichlorophenyl)acetonitrile

HRID 234936

반응식

HRID 234936 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5]Cl.[C-:11]#[N:12].[K+]>ClCCl.S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][C:11]#[N:12])[CH:7]=[C:8]([Cl:10])[CH:9]=1

참가 물질

6

반응물 2

HCID 9032Potassium CyanideHCID 1378803,5-Dichlorobenzyl chloride

생성물 1

HCID 126899782-(3,5-Dichlorophenyl)acetonitrile

시약·촉매·용매 3

HCID 94433Tetrabutylammonium hydrogen sulfate촉매HCID 962Water용매HCID 6344Dichloromethane용매2회

실험 절차

To a vigorously stirred solution of 3,5-dichlorobenzylchloride (28 g) in dichloromethane (150 ml) was added a mixture of KCN (27.5 g) and tetrabutylammonium hydrogen sulphate (2.38 g) in water (110 ml). After stirring at room temperature for 22 hours, the mixture was diluted with dichloromethane, the organic phase washed with water and concentrated in vacuo to leave an oil. Filtration through silica with toluene followed by concentration then trituration with hexane gave the desired product as a colourless solid. 15.8 g, mp. 31°-32° C.

후처리

  1. washthe organic phase washed with water
  2. concentrationconcentrated in vacuo
  3. customto leave an oil
  4. filtrationFiltration through silica with toluene
  5. concentrationfollowed by concentration

출처 및 근거

ORD 기록
ord-a2fcd0071a234bf79414e8030e9ac48a
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597827

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