2,4-Dinitrobenzoic acid → 2,4-Dinitrobenzamide

HRID 235060

반응식

[N+:1]([C:4]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[CH:9][C:5]=1[C:6](O)=[O:7])([O-:3])=[O:2].C(Cl)(=O)C(Cl)=O.[NH4+:22].[OH-]>>[N+:1]([C:4]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[CH:9][C:5]=1[C:6]([NH2:22])=[O:7])([O-:3])=[O:2]

참가 물질

반응물 3

HCID 118802,4-Dinitrobenzoic acid

HCID 14923Ammonium Hydroxide

HCID 65578Oxalyl chloride

생성물 1

HCID 37335182,4-Dinitrobenzamide수율 89%

실험 절차

2,4-Dinitrobenzoic acid (8.17 g, 38.5 mmol) was treated with oxalyl chloride (3.90 mL, 44.7 mmol). The resulting acid chloride was treated with saturated NH4OH solution (200 mL) to yield the title compound (7.25 g, 89%). m.p. 202°-204° C. 1H NMR (300 MHz, DMSO) δ8.75 (d, 1H), 8.58 (dd, 1H), 8.48 (br s, 1H), 7.99 (br s, 1H), 7.91 (d, 1H), 5.50-6.20 (br s, 2H). MS (DCI/NH3) m/e 229 (M+NH4)+.

출처 및 근거

ORD 기록: ord-31a6f5a7f71c4d809ae281e01e1ca844
출처 데이터셋: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05597823

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