Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl Thioglycolate | HCID 12185 | — |
| 반응물 | 2,4-Dinitrobenzonitrile | HCID 554082 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Methyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate | HCID 619888 | 46% |
반응 단계
The product from Example 47B (3.73 g, 19.3 mmol) was treated with 1 equivalent ethyl thioglycolate and 1 equivalent K2CO3 in ethanol by the procedure described in Example 41A to yield the title compound (2.35 g, 46%). m.p. 169°-170° C. 1H NMR (300 MHz, DMSO) δ8.90 (d, 1H), 8.37 (d, 1H), 8.20 (dd, 1H), 7.29 (br s, 2H), 4.31 (q, 2H), 1.31 (t, 3H). MS (DCI/NH3) m/e 284 (M+NH4)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05597823 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-d04c0d47fae94a77b33d7e29cc02dd36 |
| 출처 메모 | uspto-grants-1997_01 |