N-Aminomorpholine → 2,10-dihydro-10-(4-morpholinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one

HRID 2350858노트

반응식

HRID 2350858 반응식
Cl[C:2]1[C:7]([C:8]([N:10]2[CH2:14][CH2:13][N:12]=[C:11]2SC)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[N:18]1([N:17]2[C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[C:8](=[O:9])[N:10]3[CH2:14][CH2:13][N:12]=[C:11]23)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1

참가 물질

3

반응물 2

HCID 20315N-AminomorpholineHCID 143871351-(2-Chloropyridine-3-carbonyl)-2-methylthio-2-imidazoline

생성물 1

HCID 143871362,10-dihydro-10-(4-morpholinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one수율 52%

반응 조건

온도
160 °C

실험 절차

A mixture of 5.00 g (19.5 mmoles) of the product of Example 12 and 6.40 g (62.6 mmoles) of N-aminomorpholine was heated in an oil bath at 160° C. for 1 hour. The resulting mixture was cooled and partitioned between methylene chloride and water. The organic layer was dried (sodium sulfate) and concentrated. The crystalline residue was triturated with hexane. The resulting solid was collected to give 2.75 g of 2,10-dihydro-10-(4-morpholinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one. Melting point 225°-226° C. Total yield 52%. This compound exhibits the following formula: ##STR9##

후처리

  1. temperatureThe resulting mixture was cooled
  2. custompartitioned between methylene chloride and water
  3. dry with materialThe organic layer was dried (sodium sulfate)
  4. concentrationconcentrated
  5. customThe crystalline residue was triturated with hexane
  6. customThe resulting solid was collected

출처 및 근거

ORD 기록
ord-d043a53d9458470d8252831e938c34db
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04871732

반응 노트

불러오는 중…