Potassium Hydroxide → 5-Isopropylthiophene-3-carboxylic acid

HRID 235096노트

반응식

HRID 235096 반응식
[OH-:1].[K+].[CH:3]([C:6]1[S:7][CH:8]=[C:9]([CH:11]=[O:12])[CH:10]=1)([CH3:5])[CH3:4]>C(O)C.[N+]([O-])([O-])=O.[Ag+]>[CH:3]([C:6]1[S:7][CH:8]=[C:9]([C:11]([OH:1])=[O:12])[CH:10]=1)([CH3:5])[CH3:4]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 233535565-Isopropylthiophene-3-carbaldehyde

생성물 1

HCID 35250805-Isopropylthiophene-3-carboxylic acid수율 81.5%

시약·촉매·용매 2

HCID 24470Silver Nitrate촉매HCID 702Ethanol용매

실험 절차

A solution of AgNO3 (1.01 g, 5.92 mmol)in 10 mL of H20 and 15 mL of a solution of KOH (1.63 g, 40.8 mmol) were sequentially added to a solution of 760 mg (4.9 mmol) of 2-isopropyl-4-thiophene carboxaldehyde, from step 34a above, in 25 mL of ethanol. The resulting black mixture was stirred at room temperature for 2 hours and filtered. The filtrate was washed with ether, then acidified with 6N HCl and extracted with ether. The extract was washed with H2O and brine, dried over MgSO4 and concentrated to give 680 mg (81%) of the title compound as a yellow solid. mp. 64°-67° C.

후처리

  1. filtrationfiltered
  2. washThe filtrate was washed with ether
  3. extractionextracted with ether
  4. washThe extract was washed with H2O and brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-75bd90474137437a97d4623b7899fa0a
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597832

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