Sodium Methoxide → HCID 19856565, 화합물

HRID 2351035노트

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HRID 2351035 반응식
[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5](S(C)=O)=[N:6][N:7]=1.[CH3:13][O-:14].[Na+]>CO>[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5]([O:14][CH3:13])=[N:6][N:7]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 198565676-Amino-4-methyl-3-methylsulfinyl-1,2,4-triazin-5-one

생성물 1

HCID 19856565HCID 19856565, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

4.1 g of 6-amino-4-methyl-3-methylsulfinyl-1,2,4-triazin-5-one are suspended in 50 ml of absolute methanol, and 4.3 ml of 30% strength methanolic sodium methylate solution are added at room temperature. The reaction proceeds slightly exothermically and the temperature rises to 35° C. The solution is then stirred at 50° C. for 30 minutes, whereupon a colourless precipitate separates out of the clear yellow solution. The reaction mixture is evaporated and the residue is taken up in ethyl acetate and ice-water. The organic phase is separated off, dried with magnesium sulfate and evaporated. The residue is washed with a little methanol and dried. 1.6 g of 6-amino-4-methyl-3-methoxy-1,2,4-triazin-5-one with a melting point of 198°-199° C. are obtained in this manner.

후처리

  1. customrises to 35° C
  2. customThe reaction mixture is evaporated
  3. customThe organic phase is separated off
  4. dry with materialdried with magnesium sulfate
  5. customevaporated
  6. washThe residue is washed with a little methanol
  7. customdried

출처 및 근거

ORD 기록
ord-5d7ef8af482547a8a4660b0832dcef75
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04871853

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