N-Carbethoxyphthalimide → 4-(2-Nitrophenyl)-2-phthalimidobutyric acid

HRID 2351224노트

반응식

HRID 2351224 반응식
[NH2:1][CH:2]([CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-:16])=[O:15])[C:3]([OH:5])=[O:4].C(OC(N1[C:26](=[O:27])[C:25]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:24]2[C:23]1=[O:32])=O)C>C(=O)([O-])[O-].[Na+].[Na+]>[N+:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[CH2:7][CH2:6][CH:2]([N:1]1[C:26](=[O:27])[C:25]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:24]2[C:23]1=[O:32])[C:3]([OH:5])=[O:4])([O-:16])=[O:15]

참가 물질

4

반응물 2

HCID 31187N-CarbethoxyphthalimideHCID 132435482-Amino-4-(2-nitrophenyl)butyric acid

생성물 1

HCID 144072514-(2-Nitrophenyl)-2-phthalimidobutyric acid수율 70.3%

시약·촉매·용매 1

HCID 10340Sodium Carbonate용매

실험 절차

In an aqueous solution (150 ml) of 6.1 g of sodium carbonate is dissolved 11.7 g of 2-amino-4-(2-nitrophenyl)-butyric acid, and 15 g of N-ethoxycarbonylphthalimide is added to the solution under stirring. After stirring at room temperature overnight, the insoluble material is removed by filtration, and the filtrate is made weakly acidic with concentrated hydrochloric acid. The viscous material, which separates out, is admixed with 50 ml of ethanol, followed by stirring, whereby there separate out crystals. The crystals are collected by filtration and dried to give 13 g of 4-(2-nitrophenyl)-2-phtalimidobutyric acid as colorless crystals. m.p. 177°-179° C.

후처리

  1. additionis added to the solution
  2. stirringAfter stirring at room temperature overnight
  3. customthe insoluble material is removed by filtration
  4. stirringby stirring
  5. customwhereby there separate out crystals
  6. filtrationThe crystals are collected by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-b76768484a334a66947a8ed60c2811a8
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04871842

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