Aniline → Aniline, N-(2,2,2-trifluoroethyl)-

HRID 2351251

반응식

HRID 2351251 반응식
FC(F)(F)S([O-])(=O)=O.[F:9][C:10]([F:20])([F:19])[CH2:11][I+]C1C=CC=CC=1.[NH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(Cl)Cl>[F:9][C:10]([F:20])([F:19])[CH2:11][NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 10993805HCID 10993805, 화합물

생성물 1

HCID 9596Aniline, N-(2,2,2-trifluoroethyl)-수율 90.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

250 mg (0.573 mmol) of (2,2,2-trifluoroethyl)phenyliodonium trifluoromethanesulfonate, 107 mg (1.15 mmol) of aniline and 5 ml of methylene chloride were reacted and worked up in the same manner as described in Reference Example 4 to obtain 91.1 mg of N-(2,2,2-trifluoroethyl)aniline as an oily substance. Yield, 92%.

출처 및 근거

ORD 기록
ord-5d456a4c84e6411aa1338919de3e5b1a
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04873027

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