Thionyl Chloride → 5-(Chloromethyl)-3-methoxy-1,2-oxazole

HRID 2351305노트

반응식

HRID 2351305 반응식
O[CH2:2][C:3]1[O:7][N:6]=[C:5]([O:8][CH3:9])[CH:4]=1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:2][C:3]1[O:7][N:6]=[C:5]([O:8][CH3:9])[CH:4]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 106782583-Methoxy-5-isoxazolemethanol

생성물 1

HCID 100805435-(Chloromethyl)-3-methoxy-1,2-oxazole수율 70%

실험 절차

The mixture of 12.05 g of 5-hydroxymethyl-3-methoxy-isoxazole and 43 g of thionylchloride is heated to reflux for 30 minutes. After cooling, the reaction mixture is poured slowly over crushed ice and is extracted with ether. The organic phase is separated, washed with water and the solution is dried over magnesium sulfate. The solvent is evaporated then distilled in vacuo. 9.64 g of the expected product are obtained.

후처리

  1. temperatureis heated
  2. temperatureto reflux for 30 minutes
  3. temperatureAfter cooling
  4. additionthe reaction mixture is poured slowly
  5. customover crushed ice
  6. extractionis extracted with ether
  7. customThe organic phase is separated
  8. washwashed with water
  9. dry with materialthe solution is dried over magnesium sulfate
  10. customThe solvent is evaporated
  11. distillationthen distilled in vacuo

출처 및 근거

ORD 기록
ord-7d2ea957315e4ca6b0cc6ce92603213c
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04873243

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