2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine → 6,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

HRID 2351405노트

반응식

HRID 2351405 반응식
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH2:20]([N:23]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[CH2:34][CH2:35][NH2:36])[CH2:24][CH2:25][CH3:26])[CH2:21][CH3:22]>C(#N)C>[CH2:20]([N:23]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[CH2:34][CH2:35][NH:36][C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3])[CH2:24][CH2:25][CH3:26])[CH2:21][CH3:22]

참가 물질

4

반응물 2

HCID 108684382-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamineHCID 1420998311-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

생성물 1

HCID 142100836,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one수율 66%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 66% of theory. Colourless crystals, m.p. 149°-151° C. (acetonitrile).

출처 및 근거

ORD 기록
ord-0d53aea3b4ac432fb0c89643d57a42f2
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04873236

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