Triethylamine → [4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl][(4-morpholinyl)thio]amine

HRID 2351539

반응식

HRID 2351539 반응식
[N:1]1([S:7]Cl)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[F:16][C:17]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=2[Cl:35])[CH:21]=[CH:20][C:18]=1[NH2:19]>C(OCC)C>[Cl:35][C:26]1[CH:27]=[C:28]([C:31]([F:32])([F:34])[F:33])[CH:29]=[CH:30][C:25]=1[O:24][C:22]1[CH:21]=[CH:20][C:18]([NH:19][S:7][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[C:17]([F:16])[CH:23]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 122977794-Morpholinesulfenyl chlorideHCID 15595105Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-

생성물 1

HCID 15085830[4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl][(4-morpholinyl)thio]amine수율 59.3%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

The compound prepared in Example 5 (3.4 g) was dissolved in diethyl ether (10 ml). The solutionwas added to a solution of triethylamine (2.2 g) and the compound prepared in Example 1 (6.1 g) in diethyl ether (50 ml) at 15°-20° C. The solution was stirred for 20 minutes, diethyl ether was added (20 ml), the solution was washed with water, and dried. The solvent was removed by evaporation. Column chromatogrpahy on silica using 50:50 (v/v) diethyl ether-dichloromethane as eluant yielded the title compound as a brown oil (5 g).

후처리

  1. customat 15°-20° C
  2. washthe solution was washed with water
  3. customdried
  4. customThe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-4a29b51441144cc298ec7642f6f5aff3
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04873327

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