Hydrogen Peroxide → 2-Chloro-3-nitropyridine N-oxide

온도

70 °C

2-Chloro-3-nitropyridine (0.69 g, 4.35 mmol) was chilled to 0° C. and trifluoroacetic acid (9 mL) was slowly added followed by 30% hydrogen peroxide (1 mL). The solution was warmed to 70° C. for 1.5 hours, cooled to 0° C. and excess peroxide was decomposed by dropwise addition of dimethylsulfide (1 mL) and stirring 0.5 hours. The reaction was concentrated at reduced pressure onto silica gel and flash chromatographed (1×3 inches). Elution proceeded as follows: 50% ethyl acetate/hexane (175 mL), nil; 75% ethyl acetate/hexane (175 mL), 0.589 g (77%) of 2-chloro-3-nitropyridine-N-oxide as an orange solid suitable for use without further purification. A sample recrystallized from ethyl acetate/hexane had mp 98°-100° C. Analysis calculated for C5H3ClN2O3 : C, 34.41; H, 1.73; N, 16.05. Found: C, 34.75; H, 1.67; N, 15.80.

1. temperaturecooled to 0° C.
2. concentrationThe reaction was concentrated at reduced pressure onto silica gel and flash
3. customchromatographed (1×3 inches)
4. washElution
5. custom75% ethyl acetate/hexane (175 mL), 0.589 g (77%) of 2-chloro-3-nitropyridine-N-oxide as an orange solid suitable for use without further purification
6. customA sample recrystallized from ethyl acetate/hexane

ORD 기록

ord-519369656e6f400f97ba7449774f34ff

출처 데이터셋

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05597826