Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Dodecyne → 3-(1-Dodecynyl)benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Dodecyne | HCID 69821 | — |
| 반응물 | 3-Bromobenzaldehyde | HCID 76583 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(1-Dodecynyl)benzaldehyde | HCID 18372994 | 97.3% |
반응 단계
To a solution of 3-bromobenzaldehyde (26.5 g) and (25.0 g) 1-dodecyne in triethylamine (105 ml) was added bis(triphenylphosphine)palladium(II) chloride (1.73 g) followed by copper(I) iodide (0.24 g). The resultant mixture was stirred in the dark at 55° C. for 7 hrs, under nitrogen. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate and filtered. The filtrate was washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated to yield 37.7 g 3-(1-dodecynyl)benzaldehyde. The filtrate was an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05597838 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-2393b0dfd9ac4fadb8929f9d42b59074 |
| 출처 메모 | uspto-grants-1997_01 |