참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isoflurane | HCID 3763 | — |
| 반응물 | Sodium Fluoride | HCID 5235 | — |
| 생성물 | Desflurane | HCID 42113 | 31% |
반응 단계
A 1 liter autoclave (316SS, Parr) was charged with 399 g (2.2 moles) isoflurane and 84 g (2.0 moles) of sodium fluoride. The reaction mass was heated to 283° C. without stirring. After 24 hours at 283° C., the pressure was 1160 psi. The autoclave was then cooled to ca. 10° C. and the crude products (228 g) transferred by pouring into a distillation flask. Distillation through a four foot vacuum jacketed column packed with glass beads gave 73.4 g CHF2OCHFCF3. The material remaining in the distillation flask was found by GC analysis to be 99.6% isoflurane. Based on the materials isolated the percent conversion was 20% (31% yield). Details of the distillation are given below.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04874901 |
|---|
| 출처 데이터셋 | uspto-grants-1989_10 |
|---|
| ORD ID | ord-a02413e54fee42dc8d591f933fb0fd98 |
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| 출처 메모 | uspto-grants-1989_10 |
|---|
