1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one → N-(4-Methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

HRID 2352160노트

반응식

HRID 2352160 반응식
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=O.C(=O)(O)O.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH2:29])=[NH:28])=[CH:22][CH:21]=1>C(O)(C)C>[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([NH:26][C:27]2[N:29]=[C:5]([C:7]3[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=3)[CH:4]=[CH:3][N:28]=2)=[CH:24][CH:25]=1

참가 물질

4

반응물 2

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneHCID 178492308HCID 178492308, 화합물

생성물 1

HCID 14346975N-(4-Methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 14.4 g of 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one and 16.1 g of 4-methoxyphenyl guanidine carbonate in 200 ml of isopropanol was heated at reflux for 20 hours. The reaction mixture was cooled, the crude product was collected by filtration and washed with water. The material was recrystallized from isopropanol to give the desired product as light yellow crystals, mp 121°-122° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe crude product was collected by filtration
  5. washwashed with water
  6. customThe material was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-06b60842b9e140c999eac6875efd072d
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04876252

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