3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one → N-(4-Methoxyphenyl)-4-(2-thienyl)-2-pyrimidinamine

HRID 2352162

반응식

HRID 2352162 반응식
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)=O.C(=O)(O)O.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH2:28])=[NH:27])=[CH:21][CH:20]=1>C(O)(C)C>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([NH:25][C:26]2[N:28]=[C:5]([C:7]3[S:8][CH:9]=[CH:10][CH:11]=3)[CH:4]=[CH:3][N:27]=2)=[CH:23][CH:24]=1

참가 물질

4

반응물 2

HCID 6023993-(Dimethylamino)-1-(2-thienyl)-2-propen-1-oneHCID 178492308HCID 178492308, 화합물

생성물 1

HCID 14346981N-(4-Methoxyphenyl)-4-(2-thienyl)-2-pyrimidinamine수율 61.2%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 10.9 g of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one (U.S. Pat. No. 4,374,988) and 11.8 g of 4-methoxyphenylguanidine carbonate in 150 ml of isopropanol was heated at reflux for 48 hours. The solution was cooled, then filtered, giving 9.0 g of the desired product as yellow crystals, mp 158°-160° C.

후처리

  1. temperatureat reflux for 48 hours
  2. temperatureThe solution was cooled
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-dfea865d6c1641a8966b9f06b7afa17d
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04876252

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