Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl propiolate → 1,2,3,5-Tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a]pyridin-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl propiolate | HCID 13536 | — |
| 반응물 | 2-Chloro-5-{[2-(nitromethylidene)imidazolidin-1-yl]methyl}pyridine | HCID 180957 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1,2,3,5-Tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a]pyridin-5-one | HCID 14675671 | 52.3% |
반응 단계
A mixed solution of 2-nitromethylene-3-(2-chloro-5-pyridylmethyl) imidazolidine (12.7 g), propiolic acid methyl ester (4.2 g) and methanol (100 ml) was refluxed under heating for about 20 hours. Subsequently methanol was distilled off under reduced pressure, and the residue was refined by a silica-gel column chromatography to give the desired 1,2,3,5-tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a] pyridin -5-one (8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04876263 |
| 출처 데이터셋 | uspto-grants-1989_10 |
| ORD ID | ord-3b1ebd800e55400882e6e04550446e7b |
| 출처 메모 | uspto-grants-1989_10 |