Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → (E)-4-Fluorocinnamoyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-Fluorocinnamic acid | HCID 1530234 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (E)-4-Fluorocinnamoyl chloride | HCID 5706471 | 105.3% |
반응 단계
A mixture of 15.0 g. (0.09 mole) of trans-4-fluorocinnamic acid (Compound LXXVI) and 30 ml. (0.41 mole) of thionyl chloride in 100 ml. of toluene is stirred at 70° C. for 18 hours, and the solvent is evaporated at reduced pressure to obtain the crude product (17.5 g. (>100%)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04876280 |
| 출처 데이터셋 | uspto-grants-1989_10 |
| ORD ID | ord-776ffac4160a49d59cd8051d63e04376 |
| 출처 메모 | uspto-grants-1989_10 |