Pentyl nitrite → Methyl 1,3-thiazole-5-carboxylate

HRID 2352547

반응식

HRID 2352547 반응식
N[C:2]1[S:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=1.N(OCCCCC)=O>O1CCOCC1>[S:3]1[C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=[CH:2]1

참가 물질

4

반응물 2

HCID 10026Pentyl nitriteHCID 238005Methyl 2-aminothiazole-5-carboxylate

생성물 1

HCID 331117Methyl 1,3-thiazole-5-carboxylate수율 44.7%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Methyl 2-aminothiazole-5-carboxylate (79 g, 0.5 mol) was added over a period of 2 hours to a boiling solution of amyl nitrite (117.0 g, 1.0 mol) in dioxan (1 liter). After refluxing for a further half hour, the solvent was removed under reduced pressure and the residue was steam distilled to give a yellow oil which, on trituration with petroleum ether, gave the desired product as a white solid (32.0 g), m.pt. 68° C.

후처리

  1. temperatureAfter refluxing for a further half hour
  2. customthe solvent was removed under reduced pressure
  3. distillationdistilled
  4. customto give a yellow oil which

출처 및 근거

ORD 기록
ord-a951ef8f5b97400ebf540e8696ab7d79
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04877802

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