Pentyl nitrite → Methyl 1,3-thiazole-5-carboxylate
반응식
N[C:2]1[S:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=1.N(OCCCCC)=O>O1CCOCC1>[S:3]1[C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=[CH:2]1참가 물질
4
실험 절차
Methyl 2-aminothiazole-5-carboxylate (79 g, 0.5 mol) was added over a period of 2 hours to a boiling solution of amyl nitrite (117.0 g, 1.0 mol) in dioxan (1 liter). After refluxing for a further half hour, the solvent was removed under reduced pressure and the residue was steam distilled to give a yellow oil which, on trituration with petroleum ether, gave the desired product as a white solid (32.0 g), m.pt. 68° C.
후처리
- temperatureAfter refluxing for a further half hour
- customthe solvent was removed under reduced pressure
- distillationdistilled
- customto give a yellow oil which
출처 및 근거
- ORD 기록
- ord-a951ef8f5b97400ebf540e8696ab7d79
- 출처 데이터셋
- uspto-grants-1989_10
- 특허 번호
- US04877802
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