Potassium Hydroxide → 4-{[1,1'-Biphenyl]-4-yl}butanoic acid

HRID 2352573노트

반응식

HRID 2352573 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>C(O)C.O>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 19843451Ethyl 4-([1,1'-biphenyl]-4-yl)butanoate

생성물 1

HCID 111392304-{[1,1'-Biphenyl]-4-yl}butanoic acid수율 97.2%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

A solution of ethyl 4-(4-phenylphenyl)butanoate (21.0 g) and potassium hydroxide (9.65 g) in ethanol (50 ml) and water (50 ml) was heated under reflux for 2 hours. The resulting mixture was allowed to cool, diluted with water (150 ml), washed with ether (x2), acidified with concentrated hydrochloric acid, and extracted with ether. The extracts were washed with water, dried and concentrated to give crude 4-(4-phenylphenyl)butanoic acid [(3), 18.28 g] as a white solid, m.p. 111°-113° C. (D. H. Hey and R. Wilkinson, J. Chem. Soc., 1940, 1030, give a m.p. of 118°-119° C. for this acid).

후처리

  1. temperatureunder reflux for 2 hours
  2. temperatureto cool
  3. washwashed with ether (x2)
  4. extractionextracted with ether
  5. washThe extracts were washed with water
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c681ead0eda746aa8570a9e5697af6f5
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04877811

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