Thionyl Chloride → 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

온도

79 °C

A dry 25 mL flask was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (0.802 g, 4.67 mmol) and thionyl chloride (10 mL) and allowed to stir at 79° C. for 2 h. The thionyl chloride was then removed by distillation. The crude acid chloride was cooled to room temperature, and then dissolved in THF (5 mL). 5-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (0.905 g, 3.59 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux for 2 h. The reaction mixture was then allowed to cool to room temperature. The room temperature reaction mixture was concentrated in vacuo, and the crude residue was dissolved in EtOH (5 mL). The ethanolic solution was treated with 1M NaOH(aq) (2 mL) and stirred for 30 min. The basic solution was acidified to a pH of 1 with 1M HCl(aq) yielding a tan precipitate. The tan solids were filtered to afford the pure 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (1.05 g, 2.73 mmol, 76%).

1. customThe thionyl chloride was then removed by distillation
2. temperatureThe crude acid chloride was cooled to room temperature
3. dissolutiondissolved in THF (5 mL)
4. temperatureto reflux for 2 h
5. temperatureto cool to room temperature
6. customThe room temperature reaction mixture
7. concentrationwas concentrated in vacuo
8. dissolutionthe crude residue was dissolved in EtOH (5 mL)
9. additionThe ethanolic solution was treated with 1M NaOH(aq) (2 mL)
10. stirringstirred for 30 min
11. customyielding a tan precipitate
12. filtrationThe tan solids were filtered

ORD 기록

ord-07eac9c9f1e647c5b0492501e835e706

출처 데이터셋

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07749530B2