(3S)-N-Methylpiperidine-3-carboxamide → HCID 11598384, 화합물

HRID 2353158노트

반응식

HRID 2353158 반응식
[CH3:1][NH:2][C:3]([C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[S:20][C:19]3[C:18]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:17][C:16](Cl)=[N:15][C:14]=3[CH:13]=2)[CH2:6]1)=[O:4].C[NH:29][C:30]([C@H:32]1[CH2:37][CH2:36][CH2:35][NH:34][CH2:33]1)=O.Cl.N1CCC[C@@H](C(O)=O)[CH2:40]1>>[CH3:1][NH:2][C:3]([C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[S:20][C:19]3[C:18]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:17][C:16]([C:37]4[CH:36]=[CH:35][CH:40]=[C:30]5[C:32]=4[CH:33]=[N:34][NH:29]5)=[N:15][C:14]=3[CH:13]=2)[CH2:6]1)=[O:4]

참가 물질

4

반응물 3

HCID 7175807(3S)-N-Methylpiperidine-3-carboxamideHCID 24820499(3R)-Piperidine-3-carboxylic acid--hydrogen chloride (1/1)HCID 57494049HCID 57494049, 화합물

생성물 1

HCID 11598384HCID 11598384, 화합물

실험 절차

Via (S)-1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidine-3-carboxylic acid methylamide, prepared from (S)-piperidine-3-carboxylic acid methylamide. Amine preparation as for 154, utilizing (R)-(+)-nipecotic acid hydrochloride as the starting material.

출처 및 근거

ORD 기록
ord-6c0b852dd0d64cf6b641df8e3623b257
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750002B2

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