Citric Acid → Carvedilol citric acid

HRID 2353402노트

반응식

HRID 2353402 반응식
[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[CH3:14][O:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=1[O:22][CH2:23][CH2:24][NH:25][CH2:26][CH:27]([OH:43])[CH2:28][O:29][C:30]1[CH:31]=[CH:32][CH:33]=[C:34]2[NH:42][C:41]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:35]=12>>[CH3:14][O:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=1[O:22][CH2:23][CH2:24][NH:25][CH2:26][CH:27]([OH:43])[CH2:28][O:29][C:30]1[CH:31]=[CH:32][CH:33]=[C:34]2[NH:42][C:41]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:35]=12.[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4]

참가 물질

3

반응물 2

HCID 311Citric AcidHCID 2585Carvedilol

생성물 1

HCID 67390391Carvedilol citric acid

실험 절차

In a 150 mL glass beaker, 100 gram of 20% w/w citric acid solution was prepared and 2.2 gram of carvedilol was added. The solution became slightly brownish after 15 minutes stirring, with only a little solid sticking on the bottom of the beaker. The beaker was then placed in a fume hood for evaporation. After staying in the hood overnight, large single crystals appeared in the beaker. The solid crystals were isolated and dried in a desiccator under vacuum. Similarly single crystals of citrate salt could be obtained by slow evaporation of carvedilol/citric acid solutions (containing citric acid 5%, 10% or 20% w/w) in Petri dishes (150 mm diameter) placed in a desiccator connected to a house vacuum.

후처리

  1. customThe beaker was then placed in a fume hood for evaporation
  2. customAfter staying in the hood overnight, large single crystals
  3. customThe solid crystals were isolated
  4. customdried in a desiccator under vacuum

출처 및 근거

ORD 기록
ord-2e26f399fe38476195a3dff2bcd69feb
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750036B2

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