Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 7-Fluoro-2,3-dihydro-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 7-Fluoro-1H-indole | HCID 2774504 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 7-Fluoro-2,3-dihydro-1H-indole | HCID 16768261 | 54.2% |
반응 단계
7-fluoroindole (2.0 g, 14.8 mmol) was dissolved in acetic acid (6 mL) and sodium cyanoborohydride (1.87 g, 29.6 mmol) was added in 5 portions. The mixture was stirred for 1 hour then poured into 150 mL of 2N NaOH. The mixture was extracted with methylene chloride. The organics were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated to give 7-fluoroindoline (1.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07750038B2 |
| 출처 데이터셋 | uspto-grants-2010_07 |
| ORD ID | ord-74bf08cac423424aa246f19a619d4605 |
| 출처 메모 | uspto-grants-2010_07 |